- Sakura Taisen 1 & 2
- Sakura Taisen 2: Kimi, Shinitamou Koto Nakare
- Sakura Taisen 3: Paris wa Moeteiru ka
- Sakura Taisen 4: Koi Seyo, Otome
- Sakura Taisen 5: Episode 0 - Kouya no Samurai Musume
- Sakura Taisen: Atsuki Chishio Ni
- Sakura Taisen GB: Geki Hanagumi Nyuutai!
- Sakura Taisen GB2: Thunderbolt Sakusen
- Sakura Taisen Monogatari: Mysterious Paris
- Sakura Wars
- Sakura Wars: So Long, My Love
- Саквояж
- Salammbo: Battle for Carthage
- Salem
- Sally's Spa
- Salt
- Salt & Pepper: A Physics Game
- Salt and Sacrifice
- Salt and Sanctuary
- Saltsea Chronicles
- Salvation Prophecy
- Sam & Max Beyond Time and Space Remastered
- Sam & Max: Episode 202 - Moai Better Blues
- Sam & Max: Episode 203 - Night of the Raving Dead
- Sam & Max: Episode 204 - Chariots of the Dogs
- Sam & Max: Episode 205 - What's New, Beelzebub?
- Sam & Max Save the World Remastered
- Sam & Max Season 2
- Sam & Max: The Devil's Playhouse - Episode 1: The Penal Zone
- Sam & Max: The Devil's Playhouse - Episode 2: The Tomb of Sammun-Mak
- Sam & Max: The Devil's Playhouse - Episode 3: They Stole Max's Brain!
- Sam & Max: The Devil's Playhouse - Episode 4: Beyond the Alley of the Dolls
- Sam & Max: The Devil's Playhouse - Episode 5: The City That Dares Not Sleep
- Sam & Max: This Time It’s Virtual
- Samantha Swift and the Fountains of Fate
- Samantha Swift and the Golden Touch
- Samantha Swift and the Hidden Roses of Athena
- Samantha Swift and the Mystery from Atlantis
- Samaritan Paradox, The
- Samorost 2
- Samorost 3
- Samsara
- Samudai
- Samudra
- Samurai 2: Vengeance
- Samurai & Dragons
- Samurai Beatdown
- Samurai G
- Samurai Gunn
- Samurai Gunn 2
- Samurai Jack: Battle Through Time
- Samurai Maiden
- Samurai Riot
- Samurai Rush
- Samurai Shodown 2
- Samurai Shodown 3: Blades of Blood
- Samurai Shodown 4: Amakusa's Revenge
- Samurai Shodown 5
- Samurai Shodown 5 Special
- Samurai Shodown [I/1993]
- Samurai Shodown [II/2019]
- Samurai Shodown NeoGeo Collection
- Samurai Shodown: Sen
- Samurai Siege
- Samurai Vandalism
- Samurai Warriors 2
- Samurai Warriors 3
- Samurai Warriors 3: Empires
- Samurai Warriors 4
- Samurai Warriors 4-2
- Samurai Warriors 4 DX
- Samurai Warriors 4: Empires
- Samurai Warriors 5
- Samurai Warriors: Chronicles
- Samurai Warriors: Chronicles 3
- Samurai Warriors: Spirit of Sanada
- Samurai: Way of the Warrior
- Sanabi
- Sanctum 2
- Sanctum 2: Road to Elysion
- Sanctum 2: Ruins of Brightholme
- Sanctum 2: The Last Stand
- Sanctum 2: The Pursuit
- Sanctum [II/2011]
- Sand Flame
- Sand Is the Soul
- Sand Land
- Sand Slides
- Sandbox, The
- Sands of Aura
- Sands of Destruction
- Sands of Salzaar
- Sandstorm: Pirate Wars
- Sandwalkers
- Sang-Froid: Tales of Werewolves
- Sanga
- Sango 2
- Sanitarium
- Sanity of Morris
- Santa's Christmas Solitaire