- Samurai Warriors: Chronicles
- Samurai Warriors: Chronicles 3
- Samurai Warriors: Spirit of Sanada
- Sanctum 2: Road to Elysion
- Sand Slides
- Sands of Aura
- Sands of Destruction
- Sandwalkers
- Sanity of Morris
- SAS: Zombie Assault 4
- Satellite Reign
- Satisfactory
- Saturday Morning RPG
- Saturnalia
- Saurian
- Savage 2: Tortured Soul
- Savage Moon
- Save Koch
- Save the Martians
- Saving Private Sheep 2
- Saving Yello
- Savior
- Saviors of Sapphire Wings / Stranger of Sword City Revisited
- Saw 2: Flesh and Blood
- Say No! More
- Say What You See: The Collection
- SBK 2011
- SBK 22
- SBK X: Superbike World Championship
- SBK15: Official Mobile Game
- SCALE
- Scalebound
- Scarf
- Scarface: The World Is Yours
- Scarlet Blade
- Scarlet Legacy
- Scarlet Nexus
- Scars Above
- Scarygirl
- Scathe
- Scavengers
- Schein
- Schrödinger's Cat and the Raiders of the Lost Quark
- Sci-Fi Heroes
- SciAnts
- SciBeaver
- Scivelation
- Scooby-Doo! and the Spooky Swamp
- Scooby-Doo! First Frights
- Score International Baja 1000
- Scorn
- Scorpion Disfigured
- Scott Pilgrim vs. the World: The Game
- Scourge of War: Gettysburg
- Scourge: Outbreak
- Scram Kitty and His Buddy on Rails
- Scrap Metal
- Scrap Squad
- Scrapland
- Scraps: Modular Vehicle Combat
- ScreamRide
- Scribblenauts
- Scribblenauts Showdown
- Scribblenauts Unlimited
- Scribblenauts Unmasked: A DC Comics Adventure
- Scrolls
- Scrubs
- SCUM
- Scythe: Digital Edition
- SD Gundam Battle Alliance
- Sea Legends
- Sea of Solitude
- Sea of Stars
- Sea of Thieves
- Seabirds
- SeaCraft
- Seal of Evil
- Search for Amelia Earhart, The
- Season: A Letter to the Future
- Seasons After Fall
- Sébastien Loeb Rally Evo
- Second Extinction
- Second Guest, The
- Second Sight
- Secret Agent HD
- Secret Files 2: Puritas Cordis
- Secret Files 3
- Secret Files: Sam Peters
- Secret Files: Tunguska
- Secret Government
- Secret of Mana [I/1993]
- Secret of Mana [II/2018]
- Secret of Monkey Island: Special Edition, The
- Secret of Raven Rock, The
- Secret of the Solstice
- Secret Ponchos
- Secret World, The
- Secrets of Rætikon
- Section 8
- Section 8: Prejudice